What Causes Bipolar Disorder?

Bipolar disorder has no known cause, but there are many factors that are thought to be involved in its development. Heredity is the strongest predictor of bipolar disorder, and having a first-degree relative with the condition significantly increases a person’s risk. Other risk factors or potential causal factors for this condition include changes in brain structure, dysfunction in brain chemicals called neurotransmitters, and physical illnesses including autoimmune diseases and severe infections.

What is Bipolar Disorder?


As a type of mood disorder, bipolar disorder causes disturbances in mood, typically cycles between depression and mania or hypomania. Depressive episodes are very similar to major depression and cause feelings of deep sadness, loss of interest in activities, fatigue, and other symptoms. Manic episodes cause euphoria, high activity and energy levels, risky behaviors, and other unhealthy symptoms.

Bipolar disorder is a very serious mental illness that can cause significant impairments in a person’s life. Living with this condition, especially when untreated, can lead to difficulties at work, school and home, substance abuse, and even suicide. When properly diagnosed, however, bipolar disorder can be successfully treated and managed over the long-term.

Treatment often requires a period of intensive therapy in a residential setting followed by a long-term care plan with ongoing therapy and medication.

Risk Factors for Bipolar Disorder


As with most mental illnesses there is no known single or definitive cause of bipolar disorder. There likely will never be one cause found. Rather, this is a condition that is caused by multiple factors. While researchers continue to sort out what those causal factors are, they have determined that there are definite risk factors. These are factors that do not guarantee someone will develop bipolar disorder, but that do increase the risk to a significant degree:

  • Family history. This is the biggest risk factor for bipolar disorder. Having a first-degree family member with the condition can increase the risk of developing it by as much as 10 percent.
  • Stress or trauma. A stressful life event, a traumatic experience, and the resulting stress that this causes is a known risk factor for bipolar disorder and other mental illnesses.
  • Substance abuse. This is not considered a cause of bipolar disorder, but it could act as a trigger in someone already susceptible and can worsen symptoms or intensify episodes of mania or depression.

Bipolar disorder is also known to commonly co-occur with other behavioral or mental health conditions. Exactly why they are connected is not known, but the link means that they could be considered risk factors. Someone with bipolar disorder may also struggle with anxiety disorders, substance use disorders, sleep disorders, or attention deficit hyperactivity disorder.

Genes and Heredity


The strongest link between a potential cause or a risk factor and bipolar disorder is genetics. Family history is the biggest predictor of bipolar disorder. And, according to studies done with identical twins, bipolar disorder is one of the most genetically heritable of all mental illnesses. Having a close family member—a parent or sibling—is the strongest predictor of developing bipolar disorder, although it does not guarantee that someone will have the condition.

Many studies have been done to determine exactly which genes cause bipolar disorder, but it has been impossible to attribute the disease to any one gene or group of genes. What experts generally agree is that there are several genes that make a person susceptible to developing bipolar disorder and that contribute to its development. There are not, however, likely to be any genes that definitively cause it.

One reason researchers know that specific genes are not a definite cause of bipolar disorder is that studies of identical twins prove one may have the condition and the other not. Identical twins have the same genes, so if one develops bipolar disorder and the other does not, it means there are other factors involved that go beyond genetics.

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Changes in Brain Structure and Functioning


It is well known that structural, biological differences in the brain can be seen in people with bipolar disorder compared to the brains of people without the condition. Imaging technology helps researchers see structures in the brain.

The way the brain functions also differs in people with bipolar disorder. The brain uses chemicals called neurotransmitters to send signals related to mood. Measurements of neurotransmitters show that in people with bipolar disorder, this messaging is dysfunctional. Certain neurotransmitters have been specifically implicated:

  • Dopamine. Dopamine is a brain chemical that is involved in the sensation of pleasure and reward-seeking behaviors. It plays a role in the development of substance use disorders. Disruptions in the normal dopamine pathway have also been linked with schizophrenia, psychosis, and bipolar disorder.
  • Serotonin. This neurotransmitter is involved in many functions, from eating and sleeping to impulsive behaviors and memory. Dysfunction in serotonin in the brain has been connected to depression and bipolar disorder.
  • Glutamate. Glutamate is an excitatory neurotransmitter, which means it causes neurons to fire and send signals. There is recent evidence that too much glutamate could play a role in bipolar disorder. Medications that decrease the activity of glutamate are under investigation as treatment for bipolar patients.

Neurotransmitter systems are complex, but they are also strongly associated with mood. There are definite differences in how they function in the brains of people with bipolar disorder and other mental health conditions as compared to people without mental illness. Exactly how all these systems function, or dysfunction, together to impact mood is still being determined.

Autoimmune Diseases, Infections Increase Risk of Bipolar Disorder

Understanding the potential causes of bipolar disorder and other mood disorders is an important area of mental health research. One of the more recent discoveries in the study of bipolar disorder is that autoimmune diseases may play a role in the condition’s development. Studies have found that having an autoimmune disease or suffering a severe infection increases the risk of also having bipolar disorder.

In one recent study, researchers were looking for underlying causes of abnormal brain function that is seen in people with bipolar disorder and depression. The study looked at the health records of hundreds of thousands of people. The results showed that people who had ever been treated for a severe infection had a 62 percent increased risk for developing a mood disorder. Having an autoimmune disease raised the risk by 45 percent. The risk was even greater in people who had an autoimmune disease and a severe infection or multiple infections.

The study took place in Denmark, and the researchers concluded that severe infections and autoimmune disorders accounted for 12 percent of all mood disorders in the population, a significant amount. It is hard to say why there is this connection, but it could mean that infections and autoimmune diseases cause bipolar disorder, that having a mood disorder make someone more susceptible to these illnesses, or that these conditions have causes in common that are still not understood.

Mood Episode Triggers


In addition to known risk factors and contributing causes of bipolar disorder, there are several potential triggers. These are not causes of bipolar and are not necessarily risk factors but things that can trigger a period of mania or depression in someone with bipolar disorder. Mania or depression can be triggered by:

  • Insomnia
  • Certain medications, including antidepressants
  • Substance abuse
  • Pregnancy or childbirth
  • Stressful or traumatic life events, such as the death of a loved one or a job loss
  • Changes in the seasons

There is not likely to be a discovery that leads to one single and definitive cause for bipolar disorder, but as research continues, more about risk factors and contributing causes are determined. Knowing more about how the condition develops helps researchers come up with better medications and other treatments. For anyone struggling with bipolar disorder, or with some of the risk factors, being professionally evaluated is so important. A diagnosis can lead to treatment, which can effectively manage the symptoms and allow a person to feel better, have more stable moods, and function better in their everyday lives.